The Teenage Mutant Ninja Turtles (Mark Caso, Michelan Sisti, Leif Tilden, Kenn Troum) again battle their archenemy, the rogue ninja Shredder (Francois Chau). Shredder attempts revenge by obtaining the same radioactive ooze that created the Turtles and unleashing two new monstrous mutants: Tokka, an oversized snapping turtle, and Rahzar, a fearsome wolf-like creature. When Shredder plans to use the remaining ooze on himself, the Turtles must harness their ninja fighting skills to stop him.